Michael Scofield: Wentworth Miller

Lincoln Burrows: Dominic Purcell

Fernando Sucre: Amaury Nolasco

John Abruzzi: Peter Stormare

Benjamin Franklin: Rockmond Dunbar

Theodore Bagwell: Robert Knepper

David Apolskis: Lane Garrison

Charles Patoshik: Silas Weir Mitchell

Charles Westmoreland: Muse Watson

Dr. Sara Tancredi: Sarah Wayne Callies

LJ. Burrows Jr.: Marshall Allman

Veronica Donovan: Robin Tunney

Nick Savrinn: Frank Grillo

Brad Bellick: Wade Williams

Paul Kellerman: Paul Adelstein

Alexander Mahone: William Fichtner

Henry Pope: Stacy Keach